Pink1 and Parkin mutant flies both die prematurely, have degeneration of dopamine neurons, and have mitochondria with abnormal morphology and function. What happened when Parkin was overexpressed in Pink1 mutant flies?

Question

Quizplus · Accepted Answer

It is suggested that Pink1 and Parkin are in a common pathway to regulate mitochondrial function and Pink1 is upstream up Parkin. Therefore, overexpressing Parkin will rescue the mutation as it is downstream of the Pink1 mutation.

Pink1 and Parkin Mutant Flies Both Die Prematurely, Have Degeneration