Rett syndrome is caused by mutation in an X-linked gene called MeCP2. Why does mutation of this one gene cause so many neurological defects?
A) CeCP2 regulates protein synthesis by global phosphorylation of protein kinases.
B) CeCP2 causes irregular protein folding in a ubiquitous neural protein.
C) CeCP2 binds to methylated DNA and regulates gene expression.
D) CeCP2 is a histone that controls epigenetic regulation of gene expression.

Question

Quizplus · Accepted Answer

MeCP2 codes for a protein called methyl-CpG binding protein 2, which binds to and regulates genes that contain methylated DNA. Mutations in MeCP2 disrupt the normal regulation of gene expression, leading to the various neurological defects seen in Rett syndrome.

Rett Syndrome Is Caused by Mutation in an X-Linked Gene