Sites of Tissue Damage or Infection Are More Sensitive to Heat

Sites of tissue damage or infection are more sensitive to heat because:

A) there are no endogenous analgesics to inhibit nociceptive pathways.
B) molecules produced by the inflammatory response also increase the sensitivity of TRP channels to sensory stimuli via a second messenger system.
C) the neurons that modulate thermosensation are among the most easily injured or damaged.
D) the enzymes that synthesize prostaglandin are temperature-sensitive.
E) None of the above