Flies with the Shibire mutant become paralyzed at high temperatures as this destabilizes dynamin. Why would this result in paralysis? Select all that apply.
A) Actin-myosin is disrupted in muscles and they cannot contract.
B) Vesicle release is blocked.
C) Vesicle recycling is blocked.
D) Synaptic vesicles are depleted in the presynaptic terminal.

Question

Quizplus · Accepted Answer

Dynamin helps move endocytosed vesicles from the presynaptic membrane. If dynamin is destabilized it would block vesicle recycling (choice c) because endocytosis would be blocked. Because recycling is blocked synaptic vesicles in the membrane would eventually become depleted since they could not be restored (choice d). Choice (a) is incorrect as dynamin is not involved in muscle contraction. Vesicle release is not blocked because vesicles can still be released. Vesicles can still fuse with the presynaptic membrane; it is only endocytosis that is blocked.

Flies with the Shibire Mutant Become Paralyzed at High Temperatures