Deck 21: Musculoskeletal and Anti-Inflammatory Drugs

Question 1

Match each item with the correct statement below.
All may be used to treat inflammation.

A)Carisoprodol (Soma)
B)NSAIDs, corticosteroids, COX-2 inhibitors
C)bisphosphonates
D)Dantrolene (Dantrium)
E)"Silent" side effect commonly associated with prolonged NSAID use.

Answer 1

NSAIDs, corticosteroids, COX-2 inhibitors

Question 2

Used only by medical personnel during procedures; paralyze muscles.

A)Hormone replacement therapy
B)NMBAs
C)NSAIDs
D)Skeletal muscle relaxants
E)COX-2 inhibitor

Answer 2

NMBAs

Question 3

Potentiation of skeletal muscle relaxants may occur when taken with which of the following?

A) Alcohol, analgesics, psychotropic medications, and antihistamines
B) Anticoagulants, sulfonylureas, corticosteroids, and methotrexate
C) Uricosurics, antihypertensives, and lithium
D) All of the above.

Answer 3

Alcohol, analgesics, psychotropic medications, and antihistamines

Question 4

Match each item with the correct statement below.
Only skeletal muscle relaxant with direct effect on muscle; for MS, cerebral palsy not injury.

A)Carisoprodol (Soma)
B)NSAIDs, corticosteroids, COX-2 inhibitors
C)bisphosphonates
D)Dantrolene (Dantrium)
E)"Silent" side effect commonly associated with prolonged NSAID use.

Question 5

Match each item with the correct statement below.
Osteoporosis therapy

A)Carisoprodol (Soma)
B)NSAIDs, corticosteroids, COX-2 inhibitors
C)bisphosphonates
D)Dantrolene (Dantrium)
E)"Silent" side effect commonly associated with prolonged NSAID use.

Question 6

Which of the following produces estrogen agonist activity that results in increased bone mineral density to reduce fracture risk without promoting breast or endometrial cancer?

A) Hormone replacement therapy
B) Selective estrogen-receptor modifiers (SERMs)
C) Synthetic form of the hormone calcitonin
D) Bisphosphonates

Question 7

Used for postmenopausal osteoporosis prevention.

A)Hormone replacement therapy
B)NMBAs
C)NSAIDs
D)Skeletal muscle relaxants
E)COX-2 inhibitor

Question 8

Match each item with the correct statement below.
GI bleeding

A)Carisoprodol (Soma)
B)NSAIDs, corticosteroids, COX-2 inhibitors
C)bisphosphonates
D)Dantrolene (Dantrium)
E)"Silent" side effect commonly associated with prolonged NSAID use.

Question 9

Neuromuscular blocking agents, or NMBAs, are potentially very dangerous due to the risk of respiratory arrest, which is caused by _________.

A) interference with electrical impulses from the brain to the muscles of respiration
B) suppression of the receptors in the brainstem triggering respiration
C) the potential to paralyze the diaphragm
D) a decrease in the release of prostaglandins

Question 10

Oldest type of these are salicylates (aspirin); associated with GI bleeding and ulcers

A)Hormone replacement therapy
B)NMBAs
C)NSAIDs
D)Skeletal muscle relaxants
E)COX-2 inhibitor

Question 11

Used for short period of time in acute injuries for pain and spasm.

A)Hormone replacement therapy
B)NMBAs
C)NSAIDs
D)Skeletal muscle relaxants
E)COX-2 inhibitor

Question 12

The beneficial effects of NSAIDs are brought about by which action?

A) Inhibition of prostaglandin synthesis
B) Inhibition of cyclooxygenase-2 prostaglandin synthesis
C) Inhibition of calcium resorption
D) None of the above.

Question 13

Side effects with muscle relaxants include ________.

A) drowsiness, weakness, tremor, slurred speech, blurred vision, urinary problems.
B) GI ulceration and bleeding, MI, GERD, tinnitus and hearing loss, hematuria, prolonged bleeding time, and liver toxicity.
C) respiratory arrest.
D) nausea, dyspepsia, esophagitis, and abdominal, chest, bone and musculoskeletal pain.

Question 14

Which of the following are nonhormonal agents that act directly to inhibit bone reabsorption?

A) HRT
B) SERMs
C) Calcitonin
D) Bisphosphonates

Question 15

The side effects of COX-2 agents are _________.

A) "silent bleeding"
B) increased risk of hypertension, atherosclerosis, and clotting
C) suppression of both "good" and "bad" prostaglandins
D) platelet aggregation inhibition

Question 16

Which of the following instructions would be MOST appropriate for a patient receiving osteoporosis therapies?

A) "Take your medication after meals to avoid GI upset."
B) "Take your medication at bedtime."
C) "Avoid weight-bearing exercises to prevent the possibility of trauma."
D) "Do not use caffeine."

Question 17

Which response after patient education for NSAIDs and muscle relaxants indicates the need for follow up?

A) "I should take my medication with food."
B) "I should expect to notice some bleeding of my gums."
C) "I should avoid taking any other medications without checking with my doctor."
D) "I need to make sure that I drink plenty of fluids."

Question 18

NSAID does not inhibit COX-1; does not pose bleeding risks but may increase cardiac risk.

A)Hormone replacement therapy
B)NMBAs
C)NSAIDs
D)Skeletal muscle relaxants
E)COX-2 inhibitor

Question 19

Match each item with the correct statement below.
Only skeletal muscle relaxant currently a schedule drug

A)Carisoprodol (Soma)
B)NSAIDs, corticosteroids, COX-2 inhibitors
C)bisphosphonates
D)Dantrolene (Dantrium)
E)"Silent" side effect commonly associated with prolonged NSAID use.

Question 20

Which of the following medications may prevent the accelerated phase of bone loss within the first 5 years following the onset of menopause?

A) Estrogen replacement therapy
B) Selective estrogen receptor modifiers
C) Calcitonin
D) Miacalcin

Question 21

Dantrolene acts directly on skeletal muscles to manage spasticity resulting from upper motor neuron disorders.

Question 22

Salicylates are included in the category of NSAIDs.

Question 23

Peripheral edema and fluid retention are potential side effects associated with NSAIDs.

Question 24

COX-2 inhibitors may increase the risk of cardiovascular events.

Question 25

Osteoporosis most commonly affects older males.

Question 26

To be effective for treatment of osteoporosis, the largest possible dose as calculated for weight should be used when prescribing hormone replacement therapy.

Question 27

NMBAs may only be used by trained medical professionals with resuscitation equipment available.

Question 28

Most muscle relaxant drugs achieve results through direct effect on skeletal muscle.

Question 29

ALS is not effectively treated with the use of dantrolene.

Question 30

Calcitonin may be used to treat postmenopausal osteoporosis in women who refuse HRT.

Question 31

Which of the following patient education information is TRUE regarding the use of NSAIDs?

A) "Take on an empty stomach to enhance absorption."
B) "Weight gain is to be expected."
C) "Report bleeding gums to your physician."
D) "NSAIDs are a safe selection for asthmatics."