Deck 10: Cancer and Chemotherapy

Question 1

Which of the following is more likely to result from the administration of bleomycin?

A)sodium urate
B)calcium pyrophosphate
C)calcium hydroxyapatite
D)calcium oxalate
E)none of above

Answer 1

sodium urate

Question 2

Patient with metastatic bowel cancer is taking Codeine 30 mg q4h without adequate analgesia. What is the most appropriate therapy?

A)continue Codeine and add Paracetamol 1g qid
B)stop Codeine, start MS Contain l0 mg bd and Paracetamol 1g qid
C)stop Codeine, start MS Contain 20 mg bd and Paracetamol 1g qid
D)stop Codeine, start MS Contain l0 mg bd and Panadeine ii qid
E)nerve block is now indicated

Answer 2

continue Codeine and add Paracetamol 1g qid

Question 3

Concerning the prophylactic use of G-CSF during cancer chemotherapy:

A)it decreases the duration of neutropenia
B)it decreases the severity of the neutropenic nadir
C)it increases platelet numbers
D)it potentiates the effect of chemotherapy
E)it is only useful in established neutropenia

Answer 3

it decreases the severity of the neutropenic nadir

Question 4

Phase 2 trial of new cancer drug. Which is least likely to account for variation in results:

A)Size of metastases
B)Site of metastases
C)Gender
D)Performance status
E)Prior therapy

Question 5

Breast cancer, least likely defect:

A)BRCA1
B)BRCA2
C)Bcl-2
D)ATM
E)p53

Question 6

In women the biggest risk factor for breast cancer is:

A)Family history
B)Previous contra lateral breast cancer
C)Benign breast disease.
D)Hyperplasia
E)Breast feeding

Question 7

Best treatment of metastatic renal cell cancer:

A)Sutinib
B)Vindarabine
C)Palliative care
D)Bevacizumab
E)All of above

Question 8

Major spread of ovarian cancer

A)Adnexal
B)Lymphatic
C)Blood
D)Peritoneal
E)Seeding

Question 9

Patient gets bleomycin, etoposide, and cisplatin. Which cause for cessation of specific drug?

A)Infertility
B)Neutropenic sepsis
C)Interstitial lung disease
D)High frequency hearing loss
E)Vomiting

Question 10

55 year female - breast cancer 3 yrs ago had mastectomy only Presents with lower back pains. Some neurology - mild --> equivocal plantar. MRI Shows lesions in 3- 4 different vertebra - partially compressing spinal cord.

A)surgical decompression and radiotherapy
B)chemotherapy
C)oestrogen therapy
D)NSAID
E)Steroids

Question 11

Cisplatin based chemotherapy. Which anti-emetic is most effective >24 post chemotherapy:

A)Dexamethasone
B)Ondansetron
C)Tetracanniboids
D)Maxolon
E)Stemetil

Question 12

Least effective for identifying an unknown primary

A)Axillary lymphadenopathy adenocarcinoma
B)Secondary hepatic metastases adenocarcinoma
C)Mediastinal undifferentiated carcinoma
D)Bone blast secondary

Question 13

Middle aged smoker. Whole of left lung - white, collapse. Bronchoscopy shows an undifferentiated carcinoma in the left main bronchus. Presents with cough and haemoptysis. Small left clavicular lymph node palpable. Treatment:

A)Surgery
B)Radiotherapy
C)Chemotherapy
D)Palliation
E)Chemoradiation

Question 14

Smoker with carcinoma of the lung. Well until recently. Bronchoscopy shows extrinsic compression of the bronchus. Low serum sodium. Diagnosis:

A)Small cell carcinoma
B)Adenocarcinoma
C)Squamous cell carcinoma
D)Large cell carcinoma

Question 15

In a young man testicular malignancy, how does HCG cause gynaecomastia?

A)By stimulating breast directly
B)By increased testosterone
C)By increased oestrogen
D)Action of testicular tumor

Question 16

Young lady had radiotherapy for Hodgkin"s disease. 10 years later, most likely sequelae:

A)Thyroid carcinoma
B)AML
C)Non Hodgkin"s lymphoma
D)Carcinoma breast
E)Skin cancer

Question 17

DNA microsatellite - best description

A)Single locus 2 - 4 base pairs repeats
B)DNA fragments
C)CAG repeat
D)DNA folding

Question 18

Which drug is least likely to affect cytokine production - especially IL-2 in T cells?

A)Prednisone
B)Mycophenalate
C)Tacrolimus
D)Rapamycin
E)Cyclosporin A

Question 19

Among viruses which are activated due to immunosuppression the least oncogenic virus is

A)HHV8
B)CMV
C)Hepatitis B
D)EBV
E)Human papillomavirus

Question 20

Disease least likely to have a family predisposition

A)Breast cancer
B)Lung cancer
C)Germ cell cancer of testes
D)Ovarian cancer
E)Prostate cancer

Question 21

Which one of the following drugs has the least bone marrow suppression?

A)Daunorubicin
B)Cisplatin
C)Cyclophosphamide
D)Etoposide
E)Vincristine

Question 22

Most common mode of spread of epithelial ovarian tumors occurs to

A)Para aortic lymph nodes
B)Adnexae
C)Bone
D)Lungs
E)Liver

Question 23

Changes least likely with familial colonic cancer

A)APC gene mutation
B)DNA repair gene mutation
C)Chromosomal translocation
D)Microsatellite instability
E)Loss of heterozygosity for tumour suppressor genes

Question 24

Small cell lung carcinoma can cause (?all of the following except)

A)Hypercalcemia
B)Cushing"s syndrome
C)Clubbing
D)Lambert Eaton Myasthenic syndrome
E)SIADH