Many hormones are synthesized as preprohormones.A mutation in a preprohormone-encoding gene that changed the amino acid sequence of the signal peptide could result in:
A)Inability of the hormone to be secreted.
B)Decreased circulating half-life of the hormone.
C)Secretion of a smaller hormone.
D)Inability of the hormone gene to be transcribed.
E)Reduced affinity of the hormone for its receptor.

Question

Quizplus · Accepted Answer

The signal peptide is necessary for targeting the preprohormone to the endoplasmic reticulum (ER) where it will be processed and cleaved into the mature hormone. Without a functional signal peptide, the preprohormone cannot be properly translocated into the ER and will likely be degraded or stuck in the cytoplasm, resulting in an inability of the hormone to be secreted.

Many Hormones Are Synthesized as Preprohormones