A noncompetitive inhibitor decreases the rate of an enzymatic reaction by
A)binding to the active site of the enzyme.
B)changing the ∆G for the reaction.
C)changing the shape of the enzyme active site.
D)decreasing the activation energy required for the reaction.

Question

Quizplus · Accepted Answer

A noncompetitive inhibitor binds to a site on the enzyme that is not the active site, causing a conformational change in the enzyme that alters the shape of the active site. This prevents the substrate from binding to the enzyme and decreases the rate of the reaction. Choices A, B, and D all refer to mechanisms of competitive inhibition.

A Noncompetitive Inhibitor Decreases the Rate of an Enzymatic Reaction