Question 1

The radiopharmaceutical used to gather additional diagnostic information on a patient with pulmonary lesions found on CT is

Accepted Answer

^99mTc-depreotide is indicated for identification of somatostatin receptor (SSTR)-bearing pulmonary masses in patients presenting with pulmonary lesions on CT and/or chest radiography who have known malignancy or who are highly suspect for malignancy.

Question 2

Patient preparation for an ¹¹¹In-capromab pendetide imaging procedure should include

Accepted Answer

Patient preparation should include a laxative 24 hours prior to imaging and an enema on the morning of the procedure.

Question 3

A ⁶⁷Ga image at 48 hours after injection displays bowel activity; the technologist should

Accepted Answer

^99mTc-exametazime-labeled leukocytes began to be used for suspected sites of acute inflammation/infection in patients with fevers, abdominal pain, or positive blood cultures.

Question 4

The radionuclide used for imaging in the diagnostic assessment of prostate cancer is

Accepted Answer

Indium-111-capromab pendetide is an IgG₁ murine monoclonal antibody (mAB) directed toward prostate specific membrane antigen (PSMA), a glycoprotein expressed by prostate epithelium.

Question 5

A patient arrives in a nuclear medicine department for therapy for non-Hodgkin lymphoma (NHL). The radioimmunotherapy used is

Accepted Answer

⁹⁰Y-ibutumomab tiuxetan (Zevalin) is a murine IgG₁kappa monoclonal antibody directed against the CD20 antigen found on the surface of normal and malignant B cells.

Question 6

The radionuclide used in the diagnostic evaluation of recurrent or metastatic colorectal cancer is

Accepted Answer

^99mTc-arcitumomab is a fragmented antibody (Fab) generated from IMMUJ-4 and reacts with carcinoembryonic antigen (CEA), a tumor-associated antigen expressed on a variety of carcinomas found in the gastrointestinal tract.

Question 7

A patient with bilateral breast cancer is being prepared for scintimammography. The technologist will administer the ^99mTc-MIBI via

Accepted Answer

Injecting in the contralateral arm minimizes artifacts if the dose is infiltrated and minimizes false-positive uptake in the axillary lymph nodes. When there is bilateral disease, it is recommended that the radiopharmaceutical be injected in the foot for the same reason.

Question 8

In imaging with ⁶⁷Ga-citrate, target-to-background ratio increases over time because of gallium concentration in tissue

Accepted Answer

The gallium concentration in tissue remains while the target-to-background ratio increases as the blood clearance progresses over time.

Question 9

How many radionuclides are currently approved by the FDA for the treatment of bone pain?

Accepted Answer

Although numerous radionuclides have been successfully used in the treatment of bone pain, only four are currently approved by the FDA: ²²³Ra dichloride, ⁸⁹Sr-chloride, ¹⁵³Sm-lexidronam, and ³²P-sodium phosphate.

Question 10

A technologist is performing a parathyroid study using MIBI. After the flow study, the first phase (thyroid phase) of imaging should begin within

Accepted Answer

The first or thyroid phase should begin 15 to 20 minutes after injection; the second or parathyroid phase should be performed at 2 hours.

Question 11

Rituximab (Rituxan) is administered as a(n)

Accepted Answer

Administer 250 mg/m²rituximab infusion over 2 to 6 hours; then administer ⁹⁰Y-ibritumomab tiuxetan (Zevalin) 4 to 8 mL over 10 minutes.

Question 12

Among the safety instructions a technologist will provide to a patient following ⁹⁰Y-ibritumomab tiuxetan administration is to

Accepted Answer

It is recommended that a condom be used for 1 week to minimize the transfer of body fluids that are potentially contaminated with radioactive material. The effective use of contraceptive methods for 1 year is recommended for the same concern. As with any radiopharmaceutical therapy or treatment, there is the possibility of damage to a genetic structure by exposure to radioactive materials and the need for the body to repair, replace, or discard potentially damaged cells.

Question 13

Following the injection of ⁶⁷Ga-citrate, imaging can begin

Accepted Answer

Imaging with ⁶⁷Ga-citrate can begin any time from 6 hours to 1 week after injection.

Question 14

Patient preparation for a ^99mTc-depreotide study includes

Accepted Answer

Patient preparation includes hydration prior to and following injection and instructions to void urine frequently for the first few hours following injection.

Question 15

All of the following are disadvantages of ¹¹¹In-WBCs as compared to ⁶⁷Ga, EXCEPT

Accepted Answer

The drawback for ¹¹¹In-WBCs is that it requires a large volume of blood (50 ml) to be withdrawn from the patient and a 2- to 3-hour labeling procedure. The reward is that the ¹¹¹In study has a specificity of 97%, whereas the ⁶⁷Ga study has a specificity of 64%.Unfortunately, the ¹¹¹In-WBCs study has significantly lower counting statistics compared to ⁶⁷Ga and does not lend itself to delayed imaging much beyond 24 hours.

Question 16

A technologist is positioning a patient for a ⁶⁷Ga-citrate imaging study and notices that a LEAP collimator is on the camera. The recommended action for the technologist to take is to

Accepted Answer

Regardless of whether two or three photopeaks are used, a high-energy collimator is necessary to collimate the higher energies and reduce septal penetration.

Question 17

The radionuclide used to visualize primary neuroendocrine tumors is

Accepted Answer

Indium-111-pentetreotide is a radiolabeled analog of somatostatin.

Question 18

A patient's indication for a nuclear medicine study is primary pheochromocytoma. The radiopharmaceutical that the technologist prepares for administration is

Accepted Answer

Iodine-131 (¹³¹I)- or iodine-123 (¹²³I)-labeled iobenguane sulfate (AdreView) has been shown to be effective in the localization of primary or metastatic pheochromocytomas and neuroblastomas.

Question 19

Meta-iodobenzylguanidine (MIBG) acts as an analog to

Accepted Answer

MIBG is an analog of neuroepinephrine, and is taken up by the adrenergic nervous system of tissues that are derived from the neural crest.

Question 20

For optimal targeting and minimal blood pool activity,¹¹¹In-capromab pendetide imaging should begin at

Accepted Answer

Blood pool activity mapping should be imaged 30 minutes to 4 hours after injection. For optimal targeting and minimal blood pool activity, imaging should begin at 96 to 120 hours after injection.

Quiz 23: Inflammatory Tumoroncology Imaging and Therapy

The radiopharmaceutical used to gather additional diagnostic information on a patient with pulmonary lesions found on CT is

Patient preparation for an ¹¹¹In-capromab pendetide imaging procedure should include

A ⁶⁷Ga image at 48 hours after injection displays bowel activity; the technologist should

The radionuclide used for imaging in the diagnostic assessment of prostate cancer is

A patient arrives in a nuclear medicine department for therapy for non-Hodgkin lymphoma (NHL) . The radioimmunotherapy used is

The radionuclide used in the diagnostic evaluation of recurrent or metastatic colorectal cancer is

A patient with bilateral breast cancer is being prepared for scintimammography. The technologist will administer the ^99mTc-MIBI via

In imaging with ⁶⁷Ga-citrate, target-to-background ratio increases over time because of gallium concentration in tissue

How many radionuclides are currently approved by the FDA for the treatment of bone pain?

A technologist is performing a parathyroid study using MIBI. After the flow study, the first phase (thyroid phase) of imaging should begin within

Rituximab (Rituxan) is administered as a(n)

Among the safety instructions a technologist will provide to a patient following ⁹⁰Y-ibritumomab tiuxetan administration is to

Following the injection of ⁶⁷Ga-citrate, imaging can begin

Patient preparation for a ^99mTc-depreotide study includes

All of the following are disadvantages of ¹¹¹In-WBCs as compared to ⁶⁷Ga, EXCEPT

A technologist is positioning a patient for a ⁶⁷Ga-citrate imaging study and notices that a LEAP collimator is on the camera. The recommended action for the technologist to take is to

The radionuclide used to visualize primary neuroendocrine tumors is

A patient's indication for a nuclear medicine study is primary pheochromocytoma. The radiopharmaceutical that the technologist prepares for administration is

Meta-iodobenzylguanidine (MIBG) acts as an analog to

For optimal targeting and minimal blood pool activity,¹¹¹In-capromab pendetide imaging should begin at

Quiz 23: Inflammatory Tumoroncology Imaging and Therapy

The radiopharmaceutical used to gather additional diagnostic information on a patient with pulmonary lesions found on CT is

Patient preparation for an 111In-capromab pendetide imaging procedure should include

A 67Ga image at 48 hours after injection displays bowel activity; the technologist should

The radionuclide used for imaging in the diagnostic assessment of prostate cancer is

A patient arrives in a nuclear medicine department for therapy for non-Hodgkin lymphoma (NHL) . The radioimmunotherapy used is

The radionuclide used in the diagnostic evaluation of recurrent or metastatic colorectal cancer is

A patient with bilateral breast cancer is being prepared for scintimammography. The technologist will administer the 99mTc-MIBI via

In imaging with 67Ga-citrate, target-to-background ratio increases over time because of gallium concentration in tissue

How many radionuclides are currently approved by the FDA for the treatment of bone pain?

A technologist is performing a parathyroid study using MIBI. After the flow study, the first phase (thyroid phase) of imaging should begin within

Rituximab (Rituxan) is administered as a(n)

Among the safety instructions a technologist will provide to a patient following 90Y-ibritumomab tiuxetan administration is to

Following the injection of 67Ga-citrate, imaging can begin

Patient preparation for a 99mTc-depreotide study includes

All of the following are disadvantages of 111In-WBCs as compared to 67Ga, EXCEPT

A technologist is positioning a patient for a 67Ga-citrate imaging study and notices that a LEAP collimator is on the camera. The recommended action for the technologist to take is to

The radionuclide used to visualize primary neuroendocrine tumors is

A patient's indication for a nuclear medicine study is primary pheochromocytoma. The radiopharmaceutical that the technologist prepares for administration is

Meta-iodobenzylguanidine (MIBG) acts as an analog to

For optimal targeting and minimal blood pool activity, 111In-capromab pendetide imaging should begin at

Patient preparation for an ¹¹¹In-capromab pendetide imaging procedure should include

A ⁶⁷Ga image at 48 hours after injection displays bowel activity; the technologist should

A patient with bilateral breast cancer is being prepared for scintimammography. The technologist will administer the ^99mTc-MIBI via

In imaging with ⁶⁷Ga-citrate, target-to-background ratio increases over time because of gallium concentration in tissue

Among the safety instructions a technologist will provide to a patient following ⁹⁰Y-ibritumomab tiuxetan administration is to

Following the injection of ⁶⁷Ga-citrate, imaging can begin

Patient preparation for a ^99mTc-depreotide study includes

All of the following are disadvantages of ¹¹¹In-WBCs as compared to ⁶⁷Ga, EXCEPT

A technologist is positioning a patient for a ⁶⁷Ga-citrate imaging study and notices that a LEAP collimator is on the camera. The recommended action for the technologist to take is to

For optimal targeting and minimal blood pool activity,¹¹¹In-capromab pendetide imaging should begin at