Vignette #2 Sam Has Been Overweight Since the Eighth Grade

Vignette #2 Sam has been overweight since the eighth grade and is diagnosed with type 2 diabetes at his annual checkup. He tells his fiancée, Anna, who is now determined to learn as much as possible about this illness. Sam and Anna have found several reputable sites on the Internet in an attempt to help Sam reverse his condition. Let's ask several questions to see how much they have learned.
What problem is most responsible for Sam's type 2 diabetes?

A) Sam's kidneys don't excrete blood glucose efficiently.
B) A virus has triggered the destruction of pancreatic cells that produce insulin.
C) Sam's gallbladder fails to secrete bile when needed.
D) The cells in Sam's body do not respond to insulin secreted by his pancreas.
E) The pancreas is producing insufficient levels of glucagon.