A-60-year-old man is brought to the hospital after a sudden hand drop during breakfas meal and slurred speach which resolved after 20 minutes. The patient has had no shaking movements, headache, nausea, photophobia, or anxiety. He has a history of hypertension and hypercholesterolemia and takes amlodipine and rosuvastatin, respectively. His blood pressure is 120/75 mm Hg and pulse is 72/min and regular. Neurologic examination is unremarkable. Fingerstick glucose is within normal limits. ECG shows normal sinus rhythm. Carotid Doppler reveals mild left common carotid artery stenosis. MRI of the brain and echocardiogram are unremarkable. If the patient is started on an additional medication that is indicated for her condition, which of the following adverse effects is most likely to occur?

Question

A-60-year-old man is brought to the hospital after a sudden hand drop during breakfas meal and slurred speach which resolved after 20 minutes.   The patient has had no shaking movements, headache, nausea, photophobia, or anxiety. He has a history of hypertension and hypercholesterolemia and takes amlodipine and rosuvastatin, respectively.  His blood pressure is 120/75 mm Hg and pulse is 72/min and regular.  Neurologic examination is unremarkable.  Fingerstick glucose is within normal limits.  ECG shows normal sinus rhythm.  Carotid Doppler reveals mild left common carotid artery stenosis.  MRI of the brain and echocardiogram are unremarkable.  If the patient is started on an additional medication that is indicated for her condition, which of the following adverse effects is most likely to occur?

Quizplus · Accepted Answer

Eductional Objective: Gastrointestinal (GI) mucosal injury and bleeding are the most common side effects of aspirin.  These are due primarily to cyclooxygenase-1 inhibition, which results in impaired prostaglandin-dependent GI mucosal defense and decreased platelet aggregation.

A-60-Year-Old Man Is Brought to the Hospital After a Sudden