A 60-year-old man is brought to the emergency department due to persistent dyspnea. He has a history of heart failure with reduced ejection fraction. He has had no lightheadedness or chest pain. Blood pressure is 128/72 mm Hg and pulse is 81/min. After stabilization of the patient condition and medications are modified, he is discharged with the addition of a combination pill that inhibits neprilysin and blocks angiotensin II receptors. Which of the following is the most likely effect of this medication?

Question

A 60-year-old man is brought to the emergency department due to persistent dyspnea. He has a history of heart failure with reduced ejection fraction. He has had no lightheadedness or chest pain.  Blood pressure is 128/72 mm Hg and pulse is 81/min. After stabilization of the patient condition and medications are modified, he is discharged with the addition of a combination pill that inhibits neprilysin and blocks angiotensin II receptors.  Which of the following is the most likely effect of this medication?

Quizplus · Accepted Answer

Eductional Objective: Inhibition of the neprilysin leads to increase the activity of the natriuretic peptides and angiotensin II. To optimize the positive effects of the natriuretic peptides (eg, vasodilation, diuresis) while blocking the negative effects of angiotensin II (eg, vasoconstriction, fluid retention) in heart failure, a neprilysin inhibition medication should be added.

A 60-Year-Old Man Is Brought to the Emergency Department Due