A 54-year-old man comes to the physician for a routine health maintenance examination. He was diagnosed with type 2 diabetes mellitus 1 year ago. His only medication is metformin. His serum glucose is 186 mg/dL and his hemoglobin A1c is 7.6%. After discussing various medication options, it is decided to add pioglitazone to her current regime. Before starting this medication, this patient should be educated about which of the following adverse drug effects?

Question

A 54-year-old man comes to the physician for a routine health maintenance examination. He was diagnosed with type 2 diabetes mellitus 1 year ago. His only medication is metformin. His serum glucose is 186 mg/dL and his hemoglobin A1c is 7.6%. After discussing various medication options, it is decided to add pioglitazone to her current regime.  Before starting this medication, this patient should be educated about which of the following adverse drug effects?

Quizplus · Accepted Answer

Eductional Objective: Thiazolidinediones (eg, pioglitazone) can cause fluid retention, leading to peripheral edema and weight gain.  The excess fluid can potentially exacerbate underlying congestive heart failure.

A 54-Year-Old Man Comes to the Physician for a Routine