A 46-year-old man visits the office for a check-up on his mixed hyperlipidemia. His lipid levels have worsened over the last ten years as a result of gradual weight gain. The patient has tried to change his diet and exercise routine over the last six months, but his lipid levels have not improved. His medical history is unremarkable, and he is not currently on any medications. The patient does not smoke, drink alcohol, or use illegal drugs. The blood pressure is 130/86 mm Hg, the pulse rate is 76/min, and the BMI is 28 kg/m². Cardiovascular testing is normal. Which of the following drugs, when used as monotherapy, would be most likely to increase triglyceride levels in this patient?

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Eductional Objective: Bile acid-binding resins prevent bile acid enterohepatic circulation. This causes hepatic cholesterol to be diverted to the synthesis of new bile acids, increased cholesterol uptake from the circulation, and decreased blood LDL levels. Bile acid-binding resins, on the other hand, increase hepatic triglyceride production and can cause hypertriglyceridemia.

A 46-Year-Old Man Visits the Office for a Check-Up on His