A 50-year-old man comes to the physician for his annual health maintenance examination. The patient feels well. He has a history of hypertension, for which he currently takes lisinopril. He has smoked a pack of cigarettes daily for 20 years. He drinks five to six beers on weekends. He is 181 cm tall (5 ft 11 in) and weighs 80 kg (176 lb); BMI is 25 kg/m2. His pulse is 75/min, respirations are 18/min, and blood pressure is 140/85 mm Hg. Physical examination is unremarkable. Laboratory studies show: Lifestyle modification with a balanced diet, regular exercise, and reduced alcohol intake is advised. He is also started on fenofibrate therapy. This medication is most likely to help the patient by which of the following mechanisms?

Question

A 50-year-old man comes to the physician for his annual health maintenance examination. The patient feels well. He has a history of hypertension, for which he currently takes lisinopril. He has smoked a pack of cigarettes daily for 20 years. He drinks five to six beers on weekends. He is 181 cm tall (5 ft 11 in) and weighs 80 kg (176 lb); BMI is 25 kg/m2. His pulse is 75/min, respirations are 18/min, and blood pressure is 140/85 mm Hg. Physical examination is unremarkable. Laboratory studies show:  Lifestyle modification with a balanced diet, regular exercise, and reduced alcohol intake is advised.  He is also started on fenofibrate therapy.  This medication is most likely to help the patient by which of the following mechanisms?

Quizplus · Accepted Answer

Eductional Objective: Fibrates lower triglyceride levels by activating peroxisome proliferator-activated receptor alpha, which leads to decreased hepatic VLDL production and increased lipoprotein lipase activity.  Fish oil supplements containing high concentrations of omega-3 fatty acids lower triglycerides by decreasing production of VLDL and apolipoprotein B.

A 50-Year-Old Man Comes to the Physician for His Annual