A previously healthy 25-year-old man arrives at the office with penile lesions. The patient first noticed a nontender papule on his penis a month ago, and it has grown in size and number since then. He claims he has no fever, dysuria, or penile discharge. The patient has multiple sexual partners and uses condoms inconsistently. Three soft, flesh-colored papillary lesions measuring 1 cm on the dorsum of the penis are discovered during a physical examination. The inguinal lymph nodes are not enlarged, and the rest of the exam is normal. Treatment is started with a topical agent that acts as a toll-like receptor agonist to increase antiviral cytokine production. Which of the following medications was most likely prescribed to this patient?

Question

A previously healthy 25-year-old man arrives at the office with penile lesions. The patient first noticed a nontender papule on his penis a month ago, and it has grown in size and number since then. He claims he has no fever, dysuria, or penile discharge. The patient has multiple sexual partners and uses condoms inconsistently. Three soft, flesh-colored papillary lesions measuring 1 cm on the dorsum of the penis are discovered during a physical examination. The inguinal lymph nodes are not enlarged, and the rest of the exam is normal. Treatment is started with a topical agent that acts as a toll-like receptor agonist to increase antiviral cytokine production.  Which of the following medications was most likely prescribed to this patient?

Quizplus · Accepted Answer

Eductional Objective: Imiquimod is a widely used topical immunomodulatory agent that activates toll-like receptors and upregulates NF-B to stimulate a potent cellular and cytokine-based immune response to abnormal cells (e.g., human papillomavirus-infected cells in anogenital warts). Other antiproliferative effects of imiquimod include angiogenesis inhibition and apoptosis induction.

A Previously Healthy 25-Year-Old Man Arrives at the Office with Penile