Researchers looked at how various muscarinic agonists and antagonists affected the bladder's musculature. The curves shown below were created after various chemicals were applied. The impact of bethanechol, a pure cholinergic agonist, is shown by Curve A. Which of the curves most likely represents the effect of bethanechol after application of a reversible competitive antagonist?

Question

Researchers looked at how various muscarinic agonists and antagonists affected the bladder's musculature. The curves shown below were created after various chemicals were applied. The impact of bethanechol, a pure cholinergic agonist, is shown by Curve A.  Which of the curves most likely represents the effect of bethanechol after application of a reversible competitive antagonist?

Quizplus · Accepted Answer

Eductional Objective: When a reversible competitive antagonist is introduced to a full agonist, two changes in the log dose-response curve are anticipated: 1) a parallel shift to the right in the log-dose response curve showing an increase in the ED50, and 2) no change in the maximal effect (Emax).
* Noncompetitive: adjust Emax; competitive: alter ED50; move right.

Researchers Looked at How Various Muscarinic Agonists and Antagonists Affected