The anesthetic medication propofol's pharmacokinetic characteristics are being investigated by a team of researchers. Adult guinea pigs are given a single bolus of a medication formulation that has been radiolabeled. Following that, blood and tissue samples are taken at predefined intervals. Liquid scintillation counting is used to determine how much of the radioactive substance is present in the samples. The connection between drug concentration and time in different tissues is shown in the graph below. The red line on the graph most likely corresponds to which of the following tissues?

Question

The anesthetic medication propofol's pharmacokinetic characteristics are being investigated by a team of researchers. Adult guinea pigs are given a single bolus of a medication formulation that has been radiolabeled. Following that, blood and tissue samples are taken at predefined intervals. Liquid scintillation counting is used to determine how much of the radioactive substance is present in the samples. The connection between drug concentration and time in different tissues is shown in the graph below.  The red line on the graph most likely corresponds to which of the following tissues?

Quizplus · Accepted Answer

Eductional Objective: A highly lipophilic medication will be quickly transported to organs with high blood flow after intravenous administration (eg, brain, liver, kidneys, lungs). Afterward, the medication is sent to tissues with comparatively reduced blood flow (eg, skeletal muscle, fat, bone). This explains why several routinely used anesthetics, including propofol, have short acting times.

The Anesthetic Medication Propofol's Pharmacokinetic Characteristics Are Being Investigated by a Team