A 29-year-old woman comes to the office with a 2-month history of right lower quadrant pain and intermittent diarrhea. Vital signs are normal. The examination is unremarkable except for right lower quadrant tenderness. After confirmatory testing, the patient is given a delayed ileal-release medication that works by binding to a cytosolic receptor, translocating to the nucleus, and inhibiting nuclear factor-kappa-B (NF-B). The patient is most likely being treated with which of the following medications?

Question

A 29-year-old woman comes to the office with a 2-month history of right lower quadrant pain and intermittent diarrhea.  Vital signs are normal.  The examination is unremarkable except for right lower quadrant tenderness.  After confirmatory testing, the patient is given a delayed ileal-release medication that works by binding to a cytosolic receptor, translocating to the nucleus, and inhibiting nuclear factor-kappa-B (NF-B).  The patient is most likely being treated with which of the following medications?

Quizplus · Accepted Answer

Eductional Objective: Budesonide, like other glucocorticoids, reduces inflammation by binding to a cytosolic receptor, translocating into the nucleus, and inhibiting proinflammatory transcription factors such as nuclear factor-kappa-B (NF-B).  It is especially useful in reducing transmural bowel inflammation in patients with Crohn disease because it has high topical potency and limited systemic adverse effects due to high first-pass metabolism.

A 29-Year-Old Woman Comes to the Office with a 2-Month