A 50-year-old man comes to the office for medical health follow up. He is diagnosed with essential hypertension and a ramipril is prescribed for that. He has no other medical conditions. Physical examination shows unremarkable findings. Vital sings are normal and blood pressure is 123/75. Which of the following is the most likely combination of changes in response to this patient's treatment (AT = angiotensin) ?

Question

Quizplus · Accepted Answer

Eductional Objective: Angiotensin-converting enzyme (ACE) inhibitors block the effect of ACE, decreasing angiotensin II and aldosterone levels.  By decreasing angiotensin II levels, ACE inhibitors directly interrupt negative feedback loops, thereby increasing renin and angiotensin I levels.  ACE is also responsible for the breakdown of bradykinin; ACE inhibitors therefore increase bradykinin levels.

A 50-Year-Old Man Comes to the Office for Medical Health