A 55-year-old man with HIV on antiretroviral therapy comes to the physician for a follow-up examination. His HIV viral load is 559 copies/mL (N

Question

A 55-year-old man with HIV on antiretroviral therapy comes to the physician for a follow-up examination. His HIV viral load is 559 copies/mL (N<49). His physician is concerned about the development of drug resistance. Thus, his physician added a drug that is structurally unrelated to nucleosides and is not phosphorylated intracellularly.  The drug acts within the cytoplasm of infected cells to inhibit the synthesis of viral DNA from the RNA template.  Which of the following agents was most likely used in this patient?

Quizplus · Accepted Answer

Eductional Objective: Nonnucleoside reverse transcriptase inhibitors (NNRTIs) are antiretroviral drugs that do not require activation via intracellular phosphorylation.  The more common NNRTIs include nevirapine and efavirenz.

A 55-Year-Old Man with HIV on Antiretroviral Therapy Comes to the Physician