An otherwise healthy 13-year-old boy is brought to the physician because of asthma attacks that have been increasing in frequency and severity with running over the past 4 weeks. Medical history includes childhood asthma that has not required treatment for the past 5 years. The patient is prescribed a medication that reduces bronchoconstriction by inhibiting the interaction of inflammatory mediators with cell surface receptors. Which of the following drugs was most likely used in this patient?

Question

An otherwise healthy 13-year-old boy is brought to the physician because of asthma attacks that have been increasing in frequency and severity with running over the past 4 weeks. Medical history includes childhood asthma that has not required treatment for the past 5 years.  The patient is prescribed a medication that reduces bronchoconstriction by inhibiting the interaction of inflammatory mediators with cell surface receptors.  Which of the following drugs was most likely used in this patient?

Quizplus · Accepted Answer

Eductional Objective: Antagonism at leukotriene D4 receptors is the mechanism of action of zafirlukast and montelukast. Antagonized leukotriene receptors on bronchial smooth muscle cells cannot bind leukotrienes released by inflammatory cells, which results in reduced bronchoconstriction and inflammation.

An Otherwise Healthy 13-Year-Old Boy Is Brought to the Physician