A 13-year-old girl is brought to the emergency department because of severe s cough and shortness of breath. The symptoms started while she participated in a soccer tournament at her school. Her father was diagnosed with asthma as a child. Her pulse is 133/min and respirations are 35/min. Treatment with inhaled albuterol is initiated. A physician administers inhaled corticosteroid to achieve better symptom control. In addition to an anti-inflammatory effect, which of the following effects also directly occurs as a result of this therapy?

Question

A 13-year-old girl is brought to the emergency department because of severe s cough and shortness of breath. The symptoms started while she participated in a soccer tournament at her school. Her father was diagnosed with asthma as a child. Her pulse is 133/min and respirations are 35/min. Treatment with inhaled albuterol is initiated. A physician administers inhaled corticosteroid to achieve better symptom control.  In addition to an anti-inflammatory effect, which of the following effects also directly occurs as a result of this therapy?

Quizplus · Accepted Answer

Eductional Objective: In addition to their anti-inflammatory effect, Steroids (e.g., prednisolone, dexamethasone) demonstrate a permissive drug interaction with adrenergic receptor agonists (e.g., albuterol), thereby increasing the amplitude of the maximal response to adrenergic agonists. Steroids accomplish this by increasing adrenergic receptor activation and the concentration of signaling intermediates (e.g., cyclic AMP).

A 13-Year-Old Girl Is Brought to the Emergency Department Because