A 45-year-old man is brought to the emergency department due to altered mental status. His wife found him lying on the couch with difficult to arouse and anxious. His temprature is 39.5 C , pulse is 105/min, respirations are 20/min. He has a dry oral mucosal membrane with flushed skin. The pupils are dilated and poorly responsive to light. He has been diagnosed with depression and takes medications regularly, his wife thinks he might that he ingested a high dose of his medications. Which of the following drugs, if taken in overdose, would most likely cause this clinical presentation?

Question

Quizplus · Accepted Answer

Eductional Objective: Anticholinergic toxicity is characterized by fever; confusion; cutaneous flushing; dry oral mucosa; and dilated, poorly reactive pupils.  Tricyclic antidepressants, particularly amitriptyline, have strong anticholinergic effects.

A 45-Year-Old Man Is Brought to the Emergency Department Due