A researcher is developing a new antiretroviral medication to treat HIV infection. He working to add an adjuvant substance to inhibit viral proliferation in the brain. Treatment success rates improve when Drug X is combined with an adjuvant agent. Data comparing the two medication regimens is shown in the table below. Based on the data, the adjuvant agent most likely improves viral control through which of the following mechanisms?

Question

A researcher is developing a new antiretroviral medication to treat HIV infection. He working to add an adjuvant substance to inhibit viral proliferation in the brain. Treatment success rates improve when Drug X is combined with an adjuvant agent.  Data comparing the two medication regimens is shown in the table below.  Based on the data, the adjuvant agent most likely improves viral control through which of the following mechanisms?

Quizplus · Accepted Answer

Eductional Objective: P-glycoprotein is an efflux pump found on brain capillary endothelial cells (part of the blood-brain barrier) that inhibits a wide range of substrates from entering the brain.  Inhibition of p-glycoprotein can improve drug delivery to the CNS.

A Researcher Is Developing a New Antiretroviral Medication to Treat