A Pharmacist Is Trying to Study the Effect of Aminoglycoside

A pharmacist is trying to study the effect of aminoglycoside antibiotic on some disease and trying to calculate the theraputic dose for them. He finds in some cases, While calculating the appropriate dosage, he uses an adjusted body weight that is lower than the patient's actual body weight. Which of the following best explains the use of this adjusted parameter?

A) Distribution of the drug is limited to the extracellular fluid compartment
B) Elimination of the drug is predominately by hepatic clearance
C) Metabolism of the drug proceeds via zero-order kinetics
D) The drug exhibits a high degree of plasma protein binding
E) The drug is tightly sequestered within adipose tissues