Infants and Children Are Especially at Risk for Adverse Reactions

Infants and children are especially at risk for adverse reactions to medications, including age-specific adverse reactions and ineffective treatment, for which of the following reasons?

A) Drug companies make less money on pediatric clients than on other ages, so they do less research on drugs for this age group.
B) Ethical constraints related to informed consent severely limit the amount of testing of most drugs used with the pediatric population.
C) Mothers are a powerful lobbying group in Congress, the Department of Health and Human Services, and the Food and Drug Administration.
D) The response to medications varies significantly among children of similar weights and heights.