Suppose You Wanted to Investigate Ideas on How Polymerization of Prebiotic

Suppose you wanted to investigate ideas on how polymerization of prebiotic organic molecules may have occurred on the early Earth, which of the following scenarios might best be utilized for this?

A) Mix some RNA nucleotides in water and heat them to boiling temperatures.
B) Mix some amino acids (protein building blocks) in water and add a strong acid or a strong base.
C) Mix some RNA nucleotides in water and repeatedly wet and dry them on clay.
D) Mix some amino acids (protein building blocks) in water and add a bacterium harmless to humans.
E) Mix some amino acids in salt water and cool down to 0C.