Which of the following are considered goals of metabolism?
1)to make the drug more water soluble
2)to make the drug less active
3)to prepare the drug for greater distribution into adipose tissue
4)to increase the half-life of the drug

Question

Quizplus · Accepted Answer

The goal of metabolism is to convert the drug into a more water-soluble metabolite to prepare the drug for excretion.As the water solubility increases, the lipid solubility decreases.A decrease in lipid solubility makes it more difficult for the metabolite to make its way through cell membranes and so forth to reach the receptor site.As a result, the drug becomes less active than the parent compound.It is important to understand that even though the goal of metabolism is to make the drug less active in the body and to prepare the drug for excretion; this is not always the result of metabolism.

Which of the Following Are Considered Goals of Metabolism