Where will an acidic drug with a pKₐ of 3.5 have the greatest chance for absorption by passive diffusion?

Question

Quizplus · Accepted Answer

Passive diffusion depends on the presence of the drug being in the nonionized form and the concentration of the nonionized drug being higher on one side of the membrane than the other.In order for an acidic drug to be primarily in the nonionized form, the pH of the environment should be 2 units below the pKₐ of the acidic drug.This environment is found in the stomach.Thus the stomach is where there will be the greatest percentage of nonionized form of the drug and the location for the greatest chance for absorption.

Where Will an Acidic Drug with a PKₐ of 3