A 32-year-old man and his 30-year-old wife are referred for a reproductive endocrinologist infertility (REI) consult after 2 years of "trying to get pregnant." He is diagnosed with oligozoospermia. Ejaculated mature sperm are collected and undergo genetic analysis. Using gene linkage analysis, his REI specialist determines that he has aberrations in spermatogenic meiotic recombination, including both diminished frequency and suboptimal location, resulting in high frequency of aneuploid sperm. In explaining the diagnosis, she explains meiosis and recombination attributing the problem to a specific phase of the meiosis. Which part of meiosis is most closely associated with recombination?

Question

Quizplus · Accepted Answer

Recombination, or crossing over, occurs during Prophase I of meiosis. This is when homologous chromosomes pair up and exchange genetic material, which is crucial for genetic diversity and proper segregation of chromosomes.

A 32-Year-Old Man and His 30-Year-Old Wife Are Referred for a Reproductive