A 62-year-old man of African descent presents with exerciseinduced angina. His serum cholesterol is $277 \mathrm{mg} / \mathrm{dL}$ (normal

Question

A 62-year-old man of African descent presents with exerciseinduced angina. His serum cholesterol is $277 \mathrm{mg} / \mathrm{dL}$ (normal <200), LDL is 157 (normal < 100), HDL is 43 (normal > 35), and triglycerides 170 (normal < 150). His body mass index (BMI) is 34 and his coronary risk ratio is 6.84 (normal <5). Cardiac catheterization reveals an occlusion of the left anterior descending and the origin of the right coronary artery. This disease process initially involved which one of the following?

Quizplus · Accepted Answer

The initial step in the development of atherosclerosis, which leads to coronary artery disease, is injury to endothelial cells. This injury triggers a cascade of events that result in plaque formation and arterial occlusion.

A 62-Year-Old Man of African Descent Presents with Exerciseinduced Angina 277mg/dL277 \mathrm{mg} / \mathrm{dL}277mg/dL

A 62-Year-Old Man of African Descent Presents with Exerciseinduced Angina $277 \mathrm{mg} / \mathrm{dL}$