Due to the effectiveness of local anesthetic drugs, exposure of a 1 to 3 millimeter section of nerve membrane to an anesthetic solution is adequate to ensure profound anesthesia.

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Eight to ten millimeters of the nerve membrane must be flooded by an anesthetic solution in order to achieve anesthesia in larger, heavily myelinated nerves, such as the inferior alveolar nerve.

Due to the Effectiveness of Local Anesthetic Drugs, Exposure of a 1