A 2-year-old child who is a native of East Africa has been diagnosed with a deficiency in G6PDH. Following consumption of fava beans the child experiences a mild hemolytic anemia. Which of the following symptoms would also likely be present in this child?

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Favism is the term associated with the hemolytic anemia that results from the consumption of fava beans in individuals with deficiencies in G6PDH. The deficiency prevents erythrocytes from coping with the oxidative stress induced by metabolism of substances in fava beans. The continued hemolysis leads to hyperbilirubinemia, splenomegaly, and skeletal abnormalities in infants. The facial anomalies associated with favism are due to repeated episodes of intracranial hemorrhage.

A 2-Year-Old Child Who Is a Native of East Africa