A 50-year-old alcoholic male presents with pain, numbness, tingling, and weakness in his feet. He is diagnosed with thiamine deficiency. Thiamine is required as a cofactor for which of the following enzymes?

Question

Quizplus · Accepted Answer

Transketolase functions to transfer 2-carbon groups from substrates of the PPP, thus rearranging the carbon atoms that enter this pathway. Like other enzymes that transfer 2-carbon groups, transketolase requires TPP as a cofactor in the transfer reaction.

A 50-Year-Old Alcoholic Male Presents with Pain, Numbness, Tingling, and Weakness