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A 27-Year-Old Man Is Being Examined by His Physician to Ascertain

Question 3

Multiple Choice

A 27-year-old man is being examined by his physician to ascertain the cause of the bumps appearing on his skull and jaw. Close examination of the patient also shows epidermoid cysts, extra teeth, and freckle-like spots on the insides of his eyes. Family history indicates that his mother died of colorectal cancer when the patient was only 6 years old. Given the external signs apparent in this patient you recommend a colonoscopy which shows hundreds of polyps. Which of the following genes is most likely defective in this patient accounting for all of the observed symptoms?


A) APC
B) NF1
C) p53
D) RB
E) VHL

Correct Answer:

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