How does alefacept function to reduce lesions in plaque psoriasis?
A) By blocking CD28/B7 interactions and causing T cell apoptosis
B) By blocking CTLA-4/B7 interactions and causing T cell apoptosis
C) By blocking CD2/CD58 interactions and preventing T cell activation
D) By binding to CD3 on activated T cells and preventing T cell activation

Question

Quizplus · Accepted Answer

The fusion protein alefacept contains the CD58 molecule connected to an antibody. The drug will bind to endogenous CD2 on T cells, thus blocking the binding of CD2 to CD58 on the APC and preventing T cell activation.

How Does Alefacept Function to Reduce Lesions in Plaque Psoriasis