The interaction between CTLA-4 and B7 leads to:
A) Downregulation of T cell signaling
B) Stabilization of the TCR/APC interaction
C) B cell activation and generation of memory cells
D) Production of proteins that regulate the cellular response to interleukin-2 (IL-2)

Question

Quizplus · Accepted Answer

B7 molecules interact with either CD28, which leads to T cell activation, or CTLA-4, which prevents T cell activation and downregulates T cell signaling. The interaction of CD4 or CD8 molecules serves to stabilize the TCR/APC interaction. The CD40/CD40L interaction leads to B cell activation and generation of memory cells. The CD2/CD58 interaction leads to production of proteins that regulate the cellular response to IL-2.

The Interaction Between CTLA-4 and B7 Leads To