In Reference to Detecting Minimal Residual Disease, Which of the Following

In reference to detecting minimal residual disease, which of the following is true?

A) PCR, karyotyping and Southern blot analysis are equally sensitive and specific.
B) PCR is most sensitive for detecting low levels of tumor burden.
C) Karyotyping is capable of detecting 0.1% tumor burden.
D) Southern Blot analysis has 100% sensitivity and specificity for detecting aberrant proteins formed as a result of the genetic mutation.