Carbonic anhydrase inhibitors are considered to be refractory because:

Question

Quizplus · Accepted Answer

Acetazolamide is a diuretic that increases sodium and water excretion by inhibiting the enzyme carbonic anhydrase. Inhibition of carbonic anhydrase not only inhibits sodium and water reabsorption but also affects the acid-base balance of the body. This situation results in metabolic acidosis. In the presence of metabolic acidosis, excretion is enhanced, and diuresis decreases. Because the drug action is inhibited when the acid-base balance is altered, acetazolamide is considered a refractory diuretic.

Carbonic Anhydrase Inhibitors Are Considered to Be Refractory Because