In the research study discussed in the Focus on Neuroscience Box entitled "Psychotherapy and the Brain," which compared people with major depressive disorder to people without depression, those who are depressed show greater activation of the amygdala and decreased activation of the prefrontal cortex in response to cognitive tasks.

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The research study found that those who were depressed showed greater activation of the amygdala and decreased activation of the prefrontal cortex in response to cognitive tasks.

In the Research Study Discussed in the Focus on Neuroscience