Gene deletions are the cause of the majority of alpha thalassemia cases because:

Question

Quizplus · Accepted Answer

Alpha thalassemia occurs due to deletions in the alpha-globin gene cluster. The homology between the alpha-globin genes makes this region more prone to deletion errors during meiotic crossover events, leading to the loss of one or more alpha-globin genes. Therefore, option C is the correct answer that best explains the majority of alpha thalassemia cases. Options A, B, and D are incorrect as there is no gene called F1F1F1S1F1F1F10₂, and there is no evidence that transcriptional mutants cause alpha thalassemia.

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