Decreased or absent alpha-chain production will result in:

Question

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The alpha chain and gamma chain are components of fetal hemoglobin (HbF), which is the primary hemoglobin in fetal life. Decreased or absent alpha chain production will result in excess gamma chain production during fetal life and at birth, leading to a condition known as alpha-thalassemia. This excess gamma chain production can also cause the formation of abnormal hemoglobin, such as Hb Bart's, which can lead to severe anemia and other complications.

Decreased or Absent Alpha-Chain Production Will Result In