Question 1

How was it proved that CJD could be passed to another organism?

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Question 2

What appears to be the effect of reduced calorie intake on rhesus monkeys?

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Question 3

What human disease was found to be similar to kuru in the brain abnormalities it caused? What disease in sheep contributes its name to the abnormal prion molecule,PrPSC? What have been the causes of outbreaks of acquired CJD?

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Question 4

Since replication is a property characteristic of nucleic acids,how might a prion,which lacks nucleic acids,"replicate" itself?

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Question 5

What is spongiform encephalopathy?

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Question 6

When it was discovered that CJD could be acquired in addition to being inherited,why was it at first assumed that the infectious agent was a virus?

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Question 7

What evidence suggests that lower blood levels of insulin may be important in promoting longevity?

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Question 8

How was it proved that the brains of patients suffering from CJD,an inherited disease,contain an infectious agent?

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Question 9

An infectious agent is discovered that causes a particular disease.It has a relatively low molecular weight.Treatment with phenol or proteolytic enzymes,treatments that destroy proteins,render the infectious agent harmless,while treatment with nucleases and ultraviolet radiation,treatments that damage polynucleotides,has no effect.What is your interpretation of the above data and why?

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Quiz 2: The Chemical Basis of Life