Question 1

DNA glycosylase inhibitors are used to study which DNA repair mechanism?

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Question 2

Which type of mutagen has a structure similar to one of the DNA nucleotides and therefore can work its way into DNA, where it pairs with a nucleotide?

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Question 3

What type of mutagen would you use if you wanted to study the effect of pyrimidine dimers in causing cancer?

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Question 4

Which process is carried out by specialized bypass DNA that can replicate across the gaps induced during replication by UV damage?

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Question 5

What term describes a gene or region of a genome where mutations occur much more often than average?

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Question 6

Localized mutations that occur at a specific or identifiable location on a gene are better known as what?

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Question 7

Which enzyme is the product of the phr gene in E. coli?

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Question 8

What is the human cancer syndrome associated with inherited p53 mutations?

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Question 9

Which type of double-stranded break repair would you expect to be used by a cell in the G₂ phase of the cell cycle?

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Question 10

Which type of double-stranded break repair would you expect to be used by a cell in the G₁ phase of the cell cycle?

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Question 11

If you have screened 100,000 pollen grains and identified 5 mutants, what is the mutation frequency?

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Question 12

You have developed a new drug and have been asked to test the drug's mutagenicity before putting it on the market. Which test could you use to determine your compound's mutagenic potential?

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Question 13

The alkylating agent nitrosoguanidine adds methyl groups to nucleotide bases and is repaired by which enzyme that removes the added methyl group and restores nucleotides to their normal form?

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Question 14

You use several model organisms in your lab's research. Which of your model organisms would you expect to exhibit a higher mutation frequency: E. coli, D. melanogaster, or M. musculus?

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Question 15

What type of mutation commonly affects CpG islands, altering promoter regions of mammalian genes?

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Question 16

What two types of spontaneous damage to individual nucleotides are associated with subsequent mutation?

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Question 17

Which mechanism can be used to repair UV damage in Drosophila but not in humans?

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Question 18

Which repair mechanism is an error-prone system that uses bypass polymerases to replicate short segments of daughter strands whose normal replication is blocked by lesions in template strand DNA?

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Question 19

What are the two basic types of base-pair substitutions?

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Question 20

What process, which is responsible for many trinucleotide repeat disorders, alters the number of DNA repeats?

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Quiz 12: Gene Mutation, Dna Repair, and Homologous Recombination