Deck 19: Antineoplastic and Immunomodulatory Drugs

Question 1

What type of gloves should be worn to protect the skin when handling antineoplastic drugs?

A)Latex
B)Vinyl
C)Rubber
D)Leather

Answer 1

Latex

Question 2

Which of the following is the paraneoplastic syndrome that is associated with a pancreatic carcinoma?

A)Hypoglycemia
B)Cachexia
C)Anemia
D)Alopecia

Answer 2

Alopecia

Question 3

When preparing antineoplastic agents, what is used to wipe all surfaces of syringes and bottles after use?

A)Bleach
B)Cleaning agents
C)Water
D)70% alcohol

Answer 3

70% alcohol

Question 4

During which phase of the cell cycle is protein synthesized?

A)G₁ phase
B)S phase
C)M phase
D)G₂ phase

Question 5

What tumor is associated with peripheral neuropathy?

A)Lymphoma
B)Insulinoma
C)Gastrinoma
D)Carcinoma

Question 6

Which drug would be prescribed to reduce edema and suppress tumor growth?

A)Ifosfamide
B)Bleomycin
C)Mitoxantrone
D)Prednisone

Question 7

Which drugs are used to attack malignant cells?

A)Antineoplastic drugs
B)Biologic response modifying drugs
C)Immunostimulant drugs
D)Immunosuppressive drugs

Question 8

Cancerous cells lose cellular differentiation and ______.

A)regulate cell growth
B)grow with normal homeostatic control
C)exhibit anaplasia
D)inject host cells with added energy and functionality

Question 9

All of the following work on the S phase of the cell cycle except ______.

A)Cytarabine
B)Methotrexate
C)Vincristine
D)Gemcitabine

Question 10

What type of drug causes miscoding of DNA?

A)Alkylating agents
B)Antimetabolites
C)Alkaloids
D)Antitumor antibiotics

Question 11

What is used to calculate drug doses for antineoplastic drugs?

A)Tumor size
B)Body surface area
C)Body weight
D)Body weight divided by tumor size

Question 12

Antineoplastic drugs attack rapid cell division and growth regardless of whether it is needed for the body or not. Where else in the body does rapid cell division and growth occur normally for body functions?

A)Mucous membranes
B)Hair follicles
C)Urinary tract
D)Cardiovascular system

Question 13

This drug contains chemicals derived from plants. What is it?

A)Alkylating agents
B)Antimetabolites
C)Alkaloids
D)Antitumor antibiotics

Question 14

Which of the following drugs works on all phases of the cell cycle?

A)Methotrexate
B)Procarbazine
C)Vincristine
D)Gemcitabine

Question 15

What is the percentage of cancer cells that are actively dividing?

A)Doubling time
B)Growth fraction
C)Survival time
D)Pulse dosing

Question 16

What is often the first sign of malignancy?

A)Paraneoplastic syndromes
B)Alopecia
C)Infertility
D)Nephrotoxicity

Question 17

Which of the following are more effective at the S and M phases?

A)Glucocorticoids
B)Methotrexate
C)Vincristine
D)Gemcitabine

Question 18

Which of the following drugs work on all phases of the cell cycle?

A)Antibiotics
B)Alkylating agents
C)Alkaloids
D)Antimetabolites alkylating agents

Question 19

Which type of drug inhibits mitosis and causes cell death?

A)Alkylating agents
B)Antimetabolites
C)Alkaloids
D)Antitumor antibiotics

Question 20

Which of the following statements is true about antineoplastic drugs?

A)A few antineoplastic drugs are cytotoxic; therefore, careful selection is needed so that they do not interfere with normal as well as neoplastic cells.
B)Antineoplastic drugs are not cytotoxic and therefore do not interfere with normal or neoplastic cells.
C)Only some antineoplastic drugs are cytotoxic, and those interfere with normal as well as neoplastic cells.
D)All antineoplastic drugs are cytotoxic and therefore interfere with normal as well as neoplastic cells.

Question 21

The adverse effects of this biologic response modifier are bone pain, diarrhea, and anorexia. What drug is it?

A)Interferon
B)Acemannan
C)Lokivetmab
D)Filgrastim

Question 22

Which is an immune polysaccharide used in the treatment of fibrosarcomas?

A)Interferon
B)Acemannan
C)Lokivetmab
D)Filgrastim

Question 23

Which of the following is used to treat KCS in dogs, but has adverse effects of nephrotoxicity and vomiting?

A)Cyclosporine
B)Azathioprine
C)Cyclophosphamide
D)Toceranib

Question 24

How do biologic response modifiers work?

A)They interfere with one of the stages of the cell cycle.
B)They enhance the immune response against the tumor.
C)They offer a different approach to treating tumor cells.
D)They control tumor growth as an approach to treating the tumor.

Question 25

Which of the following affects cells in the S phase and is not recommended for use in cats or pregnant animals?

A)Cyclosporine
B)Azathioprine
C)Cyclophosphamide
D)Toceranib