Question 1

What type of gloves should be worn to protect the skin when handling antineoplastic drugs?

Accepted Answer

A

Question 2

Which of the following is the paraneoplastic syndrome that is associated with a pancreatic carcinoma?

Accepted Answer

D

Question 3

When preparing antineoplastic agents, what is used to wipe all surfaces of syringes and bottles after use?

Accepted Answer

70% alcohol is used to wipe all surfaces of syringes and bottles after use when preparing antineoplastic agents because it effectively disinfects and reduces the risk of contamination.

Question 4

During which phase of the cell cycle is protein synthesized?

Accepted Answer

The answer of During which phase of the cell cycle...

Question 5

What tumor is associated with peripheral neuropathy?

Accepted Answer

The answer of What tumor is associated with peripheral neuropathy?
...

Question 6

Which drug would be prescribed to reduce edema and suppress tumor growth?

Accepted Answer

Prednisone is a corticosteroid that can be prescribed to reduce inflammation and edema. It also has applications in cancer therapy to help suppress tumor growth and manage symptoms.

Question 7

Which drugs are used to attack malignant cells?

Accepted Answer

Antineoplastic drugs are specifically designed to target and destroy malignant cells, which are cancerous cells.

Question 8

Cancerous cells lose cellular differentiation and ______.

Accepted Answer

Cancerous cells exhibit anaplasia, which means they lose the structural differentiation and functional efficiency typical of normal cells. This is part of what makes them cancerous, as they grow uncontrollably and without the normal checks and balances that regulate healthy cell growth and function.

Question 9

All of the following work on the S phase of the cell cycle except ______.

Accepted Answer

Vincristine works on the M phase of the cell cycle by inhibiting microtubule formation, which is necessary for mitosis, whereas the other options are S phase-specific agents.

Question 10

What type of drug causes miscoding of DNA?

Accepted Answer

Alkylating agents cause miscoding of DNA by adding alkyl groups to the DNA molecule, which can lead to mutations during DNA replication.

Question 11

What is used to calculate drug doses for antineoplastic drugs?

Accepted Answer

Body surface area (BSA) is commonly used to calculate drug doses for antineoplastic drugs because it provides a more accurate estimation of metabolic mass than body weight, leading to more appropriate dosing for patients.

Question 12

Antineoplastic drugs attack rapid cell division and growth regardless of whether it is needed for the body or not. Where else in the body does rapid cell division and growth occur normally for body functions?

Accepted Answer

The answer of Antineoplastic drugs attack rapid cell division and...

Question 13

This drug contains chemicals derived from plants. What is it?

Accepted Answer

Alkaloids are a group of naturally occurring chemical compounds that mostly contain basic nitrogen atoms. This category includes many drugs that are derived from plants, such as morphine and quinine.

Question 14

Which of the following drugs works on all phases of the cell cycle?

Accepted Answer

Procarbazine is an alkylating agent that is non-specific to the cell cycle phases, meaning it can work on all phases.

Question 15

What is the percentage of cancer cells that are actively dividing?

Accepted Answer

The growth fraction refers to the percentage of cancer cells that are actively dividing at any given time. It is a measure of how many cells in a tumor are proliferating, which is crucial for understanding the aggressiveness of the cancer and for determining the most effective treatment strategies.

Question 16

What is often the first sign of malignancy?

Accepted Answer

Paraneoplastic syndromes can be among the first signs of malignancy, manifesting as symptoms or signs resulting from substances produced by the tumor or from an immune response against the tumor, rather than from the local presence of cancer cells. These syndromes can affect various organs and systems, often before the cancer is diagnosed.

Question 17

Which of the following are more effective at the S and M phases?

Accepted Answer

The answer of Which of the following are more effective...

Question 18

Which of the following drugs work on all phases of the cell cycle?

Accepted Answer

Alkylating agents work by attaching an alkyl group to DNA, which can occur at any phase of the cell cycle, making them effective throughout all phases.

Question 19

Which type of drug inhibits mitosis and causes cell death?

Accepted Answer

Alkaloids, specifically plant alkaloids, are known to inhibit mitosis by interfering with the microtubule function during cell division, leading to cell death. This category includes drugs like vincristine and vinblastine, which are used in cancer treatment.

Question 20

Which of the following statements is true about antineoplastic drugs?

Accepted Answer

Antineoplastic drugs are designed to target and kill rapidly dividing cells, which include both cancerous (neoplastic) and some normal cells, making them cytotoxic. This characteristic explains why these drugs often have significant side effects.

Quiz 19: Antineoplastic and Immunomodulatory Drugs