What is often the first sign of malignancy?

Name: What is often the first sign of malignancy?
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Paraneoplastic syndromes can be among the first signs of malignancy, manifesting as symptoms or signs resulting from substances produced by the tumor or from an immune response against the tumor, rather than from the local presence of cancer cells. These syndromes can affect various organs and systems, often before the cancer is diagnosed.

What Is Often the First Sign of Malignancy