Deck 4: Routes of Drug Delivery

Question 1

Which of the following routes of drug administration cannot be used to administer large quantities of drugs? (More than one answer may be correct.)

A) Intramuscular
B) Intravenous
C) Subcutaneous

Answer 1

A,C

Question 2

Sublingual route is popularly used for which of the following? (More than one answer may be correct.)

A) cardiovascular drugs
B) barbiturates
C) adhesive tablets
D) steroids

Answer 2

A,B,D

Question 3

Fill in the blank: Pulmonary epithelium is more permeable for __________ molecules when compared to the GI mucosa.

Answer 3

Hydrophilic

Question 4

Fill in the blank: Drugs after aerosol administration is deposited by three mechanisms,in which __________ helps for deposition of smaller particles,whereas larger particles are deposited by both gravitational sedimentation and __________

Question 5

Fill in the blank: A cell layer is composed of a __________ membrane and cholesterol.

Question 6

Name the drug that was first approved by U.S FDA for transdermal patch.

Question 7

Name the most relatively impermeable layer of epidermis.

Question 8

Name a few alternative approaches of drug delivery by transdermal route.

Question 9

Transdermal route of medication has gained wide acceptance when compared to _________ therapy because it is considered to be _________ route for drug delivery.

Question 10

Epithelial cells of the GI tract assist in the diffusion of most drug molecules.

Question 11

Chitosan,a mucoadhesive polymer,decreases the bioavailability of drugs.

Question 12

Administration of drugs by the intramuscular route offers uniform and slow drug absorption.

Question 13

The intra-arterial route requires dissolution of the drugs in aqueous solution.

Question 14

The intra - articular injection is given for treatment of erectile dysfunction in men.

Question 15

Oral route is better than transmucosal route for delivery of protein and peptide drugs.

Question 16

For administration of large polar molecules (<1000 DA) via the nasal route,penetration enhancers are used to ensure good bioavailability.

Question 17

A drug from the alveoli is slowly absorbed when compared to the airways of the lungs.

Question 18

Dry powder inhalers are used used for the delivery of antibiotics.

Question 19

Explain hepatic first-pass metabolism and name two drugs that undergo first-pass metabolism

Question 20

Using an example,illustrate how drug absorption is affected by food.

Question 21

Using an example,explain why PEGylation improves the safety profiles of proteins.

Question 22

Match the routes of drug administration with their respective areas of action.
Peritoneal cavity

A) Intra-articular
B) Intra-thecal
C) Intra-peritoneal
D) Intra-medullary

Question 23

How can one avoid rapid clearance of drugs from the nasal cavity?

Question 24

Compare and contrast the oral and parenteral administration of drugs.

Question 25

List the possible reasons for efficient delivery of drugs via the respiratory system:

A) Large surface area for absorption
B) Presence of oxygen
C) Blood supply
D) Diffusion of gases is fast
E) Presence of cilia
F) Thin surface for drug absorption

Question 26

Contrast transcellular and paracellular transport.

Question 27

Compare and contrast the alternative approaches: Ionotophoresis and Sonophoresis.

Question 28

Mention the three modes by which micro-needles are used for transdermal drug delivery.

Question 29

Order the five layers of the epidermal layer:
___ stratum basale
___ stratum granulosum
___ stratum corneum
___ stratum lucidum
___ stratum spinosum