Question 1

Which of the following routes of drug administration cannot be used to administer large quantities of drugs? (More than one answer may be correct.)

Accepted Answer

Intramuscular and subcutaneous routes are not suitable for administering large quantities of drugs due to limited absorption capacity and potential tissue damage.

Question 2

Sublingual route is popularly used for which of the following? (More than one answer may be correct.)

Accepted Answer

A,B,D

Question 3

Fill in the blank: Pulmonary epithelium is more permeable for __________ molecules when compared to the GI mucosa.

Accepted Answer

Hydrophilic

Question 4

Fill in the blank: Drugs after aerosol administration is deposited by three mechanisms,in which __________ helps for deposition of smaller particles,whereas larger particles are deposited by both gravitational sedimentation and __________

Accepted Answer

The answer of Fill in the blank: Drugs after aerosol...

Question 5

Fill in the blank: A cell layer is composed of a __________ membrane and cholesterol.

Accepted Answer

The answer of Fill in the blank: A cell layer...

Question 6

Name the drug that was first approved by U.S FDA for transdermal patch.

Accepted Answer

The answer of Name the drug that was first approved...

Question 7

Name the most relatively impermeable layer of epidermis.

Accepted Answer

The answer of Name the most relatively impermeable layer of...

Question 8

Name a few alternative approaches of drug delivery by transdermal route.

Accepted Answer

The answer of Name a few alternative approaches of drug...

Question 9

Transdermal route of medication has gained wide acceptance when compared to _________ therapy because it is considered to be _________ route for drug delivery.

Accepted Answer

The answer of Transdermal route of medication has gained wide...

Question 10

Epithelial cells of the GI tract assist in the diffusion of most drug molecules.

Accepted Answer

Epithelial cells of the GI tract primarily act as a barrier, and drugs often require specific transport mechanisms or must be lipophilic to diffuse across these cells.

Question 11

Chitosan,a mucoadhesive polymer,decreases the bioavailability of drugs.

Accepted Answer

Chitosan is known to enhance the bioavailability of drugs by improving their absorption through mucosal surfaces due to its mucoadhesive properties.

Question 12

Administration of drugs by the intramuscular route offers uniform and slow drug absorption.

Accepted Answer

The answer of Administration of drugs by the intramuscular route...

Question 13

The intra-arterial route requires dissolution of the drugs in aqueous solution.

Accepted Answer

The intra-arterial route involves injecting drugs directly into an artery, requiring them to be in aqueous solution to ensure proper mixing with blood and immediate therapeutic effect.

Question 14

The intra - articular injection is given for treatment of erectile dysfunction in men.

Accepted Answer

Intra-articular injections are administered into a joint space, typically for conditions like arthritis, not for erectile dysfunction, which is treated with other methods such as oral medications or penile injections.

Question 15

Oral route is better than transmucosal route for delivery of protein and peptide drugs.

Accepted Answer

The oral route is often less effective for protein and peptide drugs due to degradation in the gastrointestinal tract, whereas the transmucosal route can bypass this, offering better absorption and bioavailability.

Question 16

For administration of large polar molecules (<1000 DA) via the nasal route,penetration enhancers are used to ensure good bioavailability.

Accepted Answer

The answer of For administration of large polar molecules (<1000...

Question 17

A drug from the alveoli is slowly absorbed when compared to the airways of the lungs.

Accepted Answer

Drugs are rapidly absorbed in the alveoli due to their large surface area and rich blood supply, unlike the airways where absorption is slower.

Question 18

Dry powder inhalers are used used for the delivery of antibiotics.

Accepted Answer

Dry powder inhalers are primarily used for delivering medications to treat respiratory conditions like asthma and COPD, not typically for antibiotics.

Question 19

Explain hepatic first-pass metabolism and name two drugs that undergo first-pass metabolism

Accepted Answer

The answer of Explain hepatic first-pass metabolism and name two...

Question 20

Using an example,illustrate how drug absorption is affected by food.

Accepted Answer

The answer of Using an example,illustrate how drug absorption is...

Quiz 3: Routes of Drug Delivery